JMJD6 Polyclonal Antibody for Human(Homo sapiens) | EIAab.comJMJD6 Polyclonal Antibody for Human(Homo sapiens)

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JMJD6 (Gene name),

Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6 (Protein name ), JMJD6_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

JMJD6(KIAA0585;PTDSR);

Protein name:

Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6;

Alternative:

JmjC domain-containing protein 6;Histone arginine demethylase JMJD6;Lysyl-hydroxylase JMJD6;Jumonji domain-containing protein 6;Phosphatidylserine receptor(Protein PTDSR);Peptide-lysine 5-dioxygenase JMJD6;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Interacts with LUC7L2, LUC7L3 and U2AF2/U2AF65.

Function:

Dioxygenase that can both act as a histone arginine demethylase and a lysyl-hydroxylase. Acts as a lysyl-hydroxylase that catalyzes 5-hydroxylation on specific lysine residues of target proteins such as U2AF2/U2AF65 and LUC7L2. Acts as a regulator of RNA splicing by mediating 5-hydroxylation of U2AF2/U2AF65, affecting the pre-mRNA splicing activity of U2AF2/U2AF65. In addition to peptidyl-lysine 5-dioxygenase activity, may act as a RNA hydroxylase, as suggested by its ability to bind single strand RNA. Also acts as an arginine demethylase which demethylates histone H3 at 'Arg-2' (H3R2me) and histone H4 at 'Arg-3' (H4R3me), thereby playing a role in histone code. However, histone arginine demethylation may not constitute the primary activity in vivo. Has no histone lysine demethylase activity. Required for differentiation of multiple organs during embryogenesis. Acts as a key regulator of hematopoietic differentiation: required for angiogenic sprouting by regulating the pre-mRNA splicing activity of U2AF2/U2AF65. Seems to be necessary for the regulation of macrophage cytokine responses.

Subcellular Location:

Nucleus nucleoplasm Nucleus nucleolus Mainly found throughout the nucleoplasm outside of regions containing heterochromatic DNA, with some localization in nucleolus. During mitosis, excluded from the nucleus and reappears in the telophase of the cell cycle.

Protein Attributes:

Sequence length:

403

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

403:

SSR

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

STRING:

9606.ENSP00000394085

MIM:

604914

UniGene:

Hs.514505

String:

Q6NYC1

SMR:

Q6NYC1

KEGG:

hsa:23210

Pfam:

PF02373

Uniprot:

Q6NYC1

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ELISA Kit for Human Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6

Cat.:

E1916h

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96T

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ELISA Kit for Human Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6

Cat.:

E1916m

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Packing:

96T

ELISA Kit for Human Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6

Cat.:

E1916r

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96T

ELISA Kit for Human Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6

Cat.:

E1916b

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96T

ELISA Kit for Human Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6

Cat.:

E1916c

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96T

CLIA Kit for Human Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6

Cat.:

U1916c

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Packing:

96T

CLIA Kit for Human Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6

Cat.:

U1916m

Price:

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MSDS:

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Packing:

96T

CLIA Kit for Human Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6

Cat.:

U1916h

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MSDS:

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Packing:

96T

CLIA Kit for Human Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6

Cat.:

U1916r

Price:

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MSDS:

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Packing:

96T

CLIA Kit for Human Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6

Cat.:

U1916b

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MSDS:

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Packing:

96T

Polyclonal Antibody for Human Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6

Cat.:

P1916Rb-m

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40ug/0.2ml

Polyclonal Antibody for Human Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6

Cat.:

P1916Rb-r

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40ug/0.2ml

Polyclonal Antibody for Human Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6

Cat.:

P1916Rb-h

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6

Monoclonal Antibody for Human Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6

Protein for Human Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

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Linearity

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References

1.

"Identification of an alternative form of phosphatidylserine receptor."
Izawa M. , Takahashi M.
Submitted (2001-10) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2)
tissue: Stomach cancer.
2.

"Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro."
Nagase T. , Ishikawa K. , Miyajima N. , Tanaka A. , Kotani H. , Nomura N. , Ohara O.
DNA Res.5:31-39(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3);TISSUE SPECIFICITY
tissue: Brain.
3.

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3)
tissue: Brain.
tissue: Embryo.
4.

"DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
Zody M.C. , Garber M. , Adams D.J. , Sharpe T. , Harrow J. , Lupski J.R. , Nicholson C. , Searle S.M. , Wilming L. , Young S.K. , Abouelleil A. , Allen N.R. , Bi W. , Bloom T. , Borowsky M.L. , Bugalter B.E. , Butler J. , Chang J.L. , more...
Nature440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
5.

Mural R.J. , Istrail S. , Sutton G.G. , Florea L. , Halpern A.L. , Mobarry C.M. , Lippert R. , Walenz B. , Shatkay H. , Dew I. , Miller J.R. , Flanigan M.J. , Edwards N.J. , Bolanos R. , Fasulo D. , Halldorsson B.V. , Hannenhalli S. , Turner R. , more...
Submitted (2005-07) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
6.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
tissue: Skin.
tissue: Uterus.
7.

"Nuclear localization of the phosphatidylserine receptor protein via multiple nuclear localization signals."
Cui P. , Qin B. , Liu N. , Pan G. , Pei D.
Exp. Cell Res.293:154-163(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;NUCLEAR LOCALIZATION SIGNALS
8.

"Phosphatidylserine receptor cooperates with high-density lipoprotein receptor in recognition of apoptotic cells by thymic nurse cells."
Cao W.M. , Murao K. , Imachi H. , Hiramine C. , Abe H. , Yu X. , Dobashi H. , Wong N.C.W. , Takahara J. , Ishida T.
J. Mol. Endocrinol.32:497-505(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY;INDUCTION
9.

"Phosphatidylserine receptor in chronic pancreatitis: evidence for a macrophage independent role."
Koeninger J. , Balaz P. , Wagner M. , Shi X. , Cima I. , Zimmermann A. , di Sebastiano P. , Buechler M.W. , Friess H.
Ann. Surg.241:144-151(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY
10.

"JMJD6 is a histone arginine demethylase."
Chang B. , Chen Y. , Zhao Y. , Bruick R.K.
Science318:444-447(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION AS HISTONE DEMETHYLASE;MUTAGENESIS OF HIS-187; ASP-189 AND HIS-273
11.

"Jmjd6 catalyses lysyl-hydroxylation of U2AF65, a protein associated with RNA splicing."
Webby C.J. , Wolf A. , Gromak N. , Dreger M. , Kramer H. , Kessler B. , Nielsen M.L. , Schmitz C. , Butler D.S. , Yates J.R. III , Delahunty C.M. , Hahn P. , Lengeling A. , Mann M. , Proudfoot N.J. , Schofield C.J. , Boettger A.
Science325:90-93(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION AS LYSYL-HYDROXYLASE;COFACTOR;INTERACTION WITH LUC7L2; LUC7L3 AND U2AF2;MUTAGENESIS OF HIS-187 AND ASP-189
12.

"Analysis of Jmjd6 cellular localization and testing for its involvement in histone demethylation."
Hahn P. , Wegener I. , Burrells A. , Bose J. , Wolf A. , Erck C. , Butler D. , Schofield C.J. , Bottger A. , Lengeling A.
PLoS ONE5:E13769-E13769(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;RNA-BINDING;FUNCTION
13.

"Initial characterization of the human central proteome."
Burkard T.R. , Planyavsky M. , Kaupe I. , Breitwieser F.P. , Buerckstuemmer T. , Bennett K.L. , Superti-Furga G. , Colinge J.
BMC Syst. Biol.5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
14.

"The Brd4 extraterminal domain confers transcription activation independent of pTEFb by recruiting multiple proteins, including NSD3."
Rahman S. , Sowa M.E. , Ottinger M. , Smith J.A. , Shi Y. , Harper J.W. , Howley P.M.
Mol. Cell. Biol.31:2641-2652(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH BRD4
15.

"Crystal structure of the 2-oxoglutarate- and Fe(II)-dependent lysyl hydroxylase JMJD6."
Mantri M. , Krojer T. , Bagg E.A. , Webby C.J. , Butler D.S. , Kochan G. , Kavanagh K.L. , Oppermann U. , McDonough M.A. , Schofield C.J.
J. Mol. Biol.401:211-222(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.75 ANGSTROMS) OF 1-335 IN COMPLEX WITH NICKEL IONS;FUNCTION;BIOPHYSICOCHEMICAL PROPERTIES;MUTAGENESIS OF TYR-131; LYS-204; GLU-231; THR-285 AND ASN-287
16.

"Interaction of JMJD6 with single-stranded RNA."
Hong X. , Zang J. , White J. , Wang C. , Pan C.H. , Zhao R. , Murphy R.C. , Dai S. , Henson P. , Kappler J.W. , Hagman J. , Zhang G.
Proc. Natl. Acad. Sci. U.S.A.107:14568-14572(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.7 ANGSTROMS) OF 1-334 IN COMPLEX WITH IRON IONS AND 2-OXOGLUTARATE;POSSIBLE FUNCTION;RNA-BINDING

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